Journal article
High-throughput phenogenotyping of Mycobacteria tuberculosis clinical strains reveals bacterial determinants of treatment outcomes.
Sydney Stanley, Caitlin N Spaulding, Qingyun Liu, Michael R Chase, Dang Thi Minh Ha, Phan Vuong Khac Thai, Nguyen Huu Lan, Do Dang Anh Thu, Nguyen Le Quang, Jessica Brown, Nathan D Hicks, Xin Wang, Maximillian Marin, Nicole C Howard, Andrew J Vickers, Wiktor M Karpinski, Michael C Chao, Maha R Farhat, Maxine Caws, Sarah J Dunstan Show all
bioRxiv | Published : 2023
Abstract
BACKGROUND: Combatting the tuberculosis (TB) epidemic caused by Mycobacterium tuberculosis ( Mtb ) necessitates a better understanding of the factors contributing to patient clinical outcomes and transmission. While host and environmental factors have been evaluated, the impact of Mtb genetic background and phenotypic diversity is underexplored. Previous work has made associations between Mtb genetic lineages and some clinical and epidemiological features, but the bacterial traits underlying these connections are largely unknown. METHODS: We developed a high-throughput functional genomics platform for defining genotype-phenotype relationships across a panel of Mtb clinical isolates. These ph..
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